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ARHGDIB Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P52566 |
|---|---|
| Clone Names | 100427170 |
| Gene ID | 397 |
|---|---|
| Other Names | Rho GDP-dissociation inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13743b was selected from the C-term region of ARHGDIB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ARHGDIB |
|---|---|
| Synonyms | GDIA2, GDID4, RAP1GN1 |
| Function | Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133). |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Detected in bone marrow, thymus and spleen. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the Rho (or ARH) protein family (see MIM165390) and other Ras-related small GTP-binding proteins (see MIM179520) are involved in diverse cellular events, including cellsignaling, proliferation, cytoskeletal organization, and secretion.The GTP-binding proteins are active only in the GTP-bound state. Atleast 3 classes of proteins tightly regulate cycling between theGTP-bound and GDP-bound states: GTPase-activating proteins (GAPs),guanine nucleotide-releasing factors (GRFs), and GDP-dissociationinhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rateof GDP dissociation from Ras-like GTPases (summary by Scherle etal., 1993 [PubMed 8356058]).
References
Niu, H., et al. Oncol. Rep. 24(2):465-471(2010)Zhen, H., et al. Int. J. Gynecol. Cancer 20(3):316-322(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Said, N., et al. Cancer Metastasis Rev. 28 (3-4), 327-333 (2009) :Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
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