|Other Names||Rho GDP-dissociation inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13743b was selected from the C-term region of ARHGDIB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GDIA2, GDID4, RAP1GN1|
|Function||Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Detected in bone marrow, thymus and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
Members of the Rho (or ARH) protein family (see MIM165390) and other Ras-related small GTP-binding proteins (see MIM179520) are involved in diverse cellular events, including cellsignaling, proliferation, cytoskeletal organization, and secretion.The GTP-binding proteins are active only in the GTP-bound state. Atleast 3 classes of proteins tightly regulate cycling between theGTP-bound and GDP-bound states: GTPase-activating proteins (GAPs),guanine nucleotide-releasing factors (GRFs), and GDP-dissociationinhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rateof GDP dissociation from Ras-like GTPases (summary by Scherle etal., 1993 [PubMed 8356058]).
Niu, H., et al. Oncol. Rep. 24(2):465-471(2010)Zhen, H., et al. Int. J. Gynecol. Cancer 20(3):316-322(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Said, N., et al. Cancer Metastasis Rev. 28 (3-4), 327-333 (2009) :Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
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