|Other Names||C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2, CCR10, GPR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13744a was selected from the N-term region of CCR10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.|
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Provided below are standard protocols that you may find useful for product applications.
Chemokines are a group of small (approximately 8 to 14kD), mostly basic, structurally related molecules that regulatecell trafficking of various types of leukocytes throughinteractions with a subset of 7-transmembrane, G protein-coupledreceptors. Chemokines also play fundamental roles in thedevelopment, homeostasis, and function of the immune system, andthey have effects on cells of the central nervous system as well ason endothelial cells involved in angiogenesis or angiostasis.Chemokines are divided into 2 major subfamilies, CXC and CC, basedon the arrangement of the first 2 of the 4 conserved cysteineresidues; the 2 cysteines are separated by a single amino acid inCXC chemokines and are adjacent in CC chemokines. CCR10 is thereceptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactionsare involved in T cell-mediated skin inflammation (Homey et al.,2002 [PubMed 11821900]).
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Fujimoto, S., et al. Cytokine 44(1):172-178(2008)Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)Lambert, N.A. Sci Signal 1 (25), RE5 (2008) :Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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