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CSK Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P41240
Clone Names 100427187
Peptide ID 100427187
Additional Information
Gene ID 1445
Other Names Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL, CSK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13748a was selected from the N-term region of CSK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSK
Function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Cellular Location Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts.
Tissue Location Expressed in lung and macrophages.
Research Areas
Citations (0)

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Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.


Niu, W., et al. Clin. Chim. Acta 411 (19-20), 1491-1495 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Mikkola, E.T., et al. J. Mol. Biol. 399(4):618-627(2010)Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)

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$ 80.00
Cat# BP13748a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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