|Other Names||Matrix metalloproteinase-15, MMP-15, 3424-, Membrane-type matrix metalloproteinase 2, MT-MMP 2, MTMMP2, Membrane-type-2 matrix metalloproteinase, MT2-MMP, MT2MMP, SMCP-2, MMP15|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13751a was selected from the N-term region of MMP15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.|
|Cellular Location||Membrane; Single-pass type I membrane protein; Extracellular side|
|Tissue Location||Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. However, the protein encoded by thisgene is a member of the membrane-type MMP (MT-MMP) subfamily; eachmember of this subfamily contains a potential transmembrane domainsuggesting that these proteins are expressed at the cell surfacerather than secreted.
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Nalpas, B., et al. Gut 59(8):1120-1126(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :Mohammad, M.A., et al. Int. J. Biol. Markers 25(2):69-74(2010)
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