|Other Names||Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, PPP3CA, CALNA, CNA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13757b was selected from the C-term region of PPP3CA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.|
|Cellular Location||Cell membrane. Cell membrane, sarcolemma. Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
He, Z.H., et al. Eur. J. Appl. Physiol. 110(4):761-767(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Chiocco, M.J., et al. Subst Use Misuse 45(11):1809-1826(2010)Yang, D., et al. Int. J. Mol. Med. 26(1):159-164(2010)Bollo, M., et al. PLoS ONE 5 (8), E11925 (2010) :
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