|Other Names||Napsin-A, 3423-, Aspartyl protease 4, ASP4, Asp 4, Napsin-1, TA01/TA02, NAPSA, NAP1, NAPA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13772b was selected from the C-term region of NAPSA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in processing of pneumocyte surfactant precursors.|
|Tissue Location||Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
The activation peptides of aspartic proteinases plays roleas inhibitors of the active site. These peptide segments, orpro-parts, are deemed important for correct folding, targeting, andcontrol of the activation of aspartic proteinase zymogens. Thepronapsin A gene is expressed predominantly in lung and kidney. Itstranslation product is predicted to be a fully functional,glycosylated aspartic proteinase precursor containing an RGD motifand an additional 18 residues at its C-terminus. [provided byRefSeq].
Bishop, J.A., et al. Hum. Pathol. 41(1):20-25(2010)Woischnik, M., et al. Eur. Respir. J. 31(6):1197-1204(2008)Ueno, T., et al. Lab. Invest. 88(3):256-263(2008)Innocenti, M., et al. Nat. Cell Biol. 6(4):319-327(2004)Brasch, F., et al. J. Biol. Chem. 278(49):49006-49014(2003)
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