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CBX5 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P45973
Clone Names 100430097
Peptide ID 100430097
Additional Information
Gene ID 23468
Other Names Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha, CBX5, HP1A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13779c was selected from the Center region of CBX5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX5
Synonyms HP1A
Function Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Cellular Location Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase
Research Areas
Citations (0)

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This gene encodes a highly conserved nonhistone protein,which is a member of the heterochromatin protein family. Theprotein is enriched in the heterochromatin and associated withcentromeres. The protein has a single N-terminal chromodomain whichcan bind to histone proteins via methylated lysine residues, and aC-terminal chromo shadow-domain (CSD) which is responsible for thehomodimerization and interaction with a number ofchromatin-associated nonhistone proteins. The encoded product isinvolved in the formation of functional kinetochore throughinteraction with essential kinetochore proteins. The gene has apseudogene located on chromosome 3. Multiple alternatively splicedvariants, encoding the same protein, have been identified.


Nozawa, R.S., et al. Nat. Cell Biol. 12(7):719-727(2010)Zeng, W., et al. Epigenetics 5(4):287-292(2010)Emelyanov, A.V., et al. J. Biol. Chem. 285(20):15027-15037(2010)Kiyomitsu, T., et al. J. Cell Biol. 188(6):791-807(2010)Chaturvedi, P., et al. PLoS ONE 5 (5), E10620 (2010) :

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$ 80.00
Cat# BP13779c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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