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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   NFKBIB Antibody (C-term) Blocking peptide   

NFKBIB Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q15653
Clone Names 100430111
Peptide ID 100430111
Additional Information
Gene ID 4793
Other Names NF-kappa-B inhibitor beta, NF-kappa-BIB, I-kappa-B-beta, IkB-B, IkB-beta, IkappaBbeta, Thyroid receptor-interacting protein 9, TR-interacting protein 9, TRIP-9, NFKBIB, IKBB, TRIP9
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13780b was selected from the C-term region of NFKBIB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms IKBB, TRIP9
Function Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed in all tissues examined.
Research Areas
Citations (0)

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NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL(MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form theNFKB complex. The NFKB complex is inhibited by I-kappa-B proteins(NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B bytrapping it in the cytoplasm. Phosphorylation of serine residues onthe I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM603258) marks them for destruction via the ubiquitination pathway,thereby allowing activation of the NF-kappa-B complex. ActivatedNFKB complex translocates into the nucleus and binds DNA atkappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or Gpurine; and Y is a C or T pyrimidine).


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Potter, C., et al. Ann. Rheum. Dis. 69(7):1315-1320(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 80.00
Cat# BP13780b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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