|Other Names||Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305, LAIR1, CD305|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13784c was selected from the Center region of LAIR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.|
|Cellular Location||Cell membrane; Single- pass type I membrane protein|
|Tissue Location||Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an inhibitory receptorfound on peripheral mononuclear cells, including NK cells, T cells,and B cells. Inhibitory receptors regulate the immune response toprevent lysis of cells recognized as self. The gene is a member ofboth the immunoglobulin superfamily and the leukocyte-associatedinhibitory receptor family. The gene maps to a region of 19q13.4called the leukocyte receptor cluster, which contains at least 29genes encoding leukocyte-expressed receptors of the immunoglobulinsuperfamily.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Brondijk, T.H., et al. Blood 115(7):1364-1373(2010)Tang, X., et al. J. Immunol. 182(9):5446-5452(2009)Lebbink, R.J., et al. Matrix Biol. 28(4):202-210(2009)Xue, J.N., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24(4):373-374(2008)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.