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RORC Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P51449
Clone Names 100430149
Peptide ID 100430149
Additional Information
Gene ID 6097
Other Names Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR-related orphan receptor C, Retinoid-related orphan receptor-gamma, RORC, NR1F3, RORG, RZRG
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13786c was selected from the Center region of RORC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NR1F3, RORG, RZRG
Function Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25- hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue- selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC- mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A. Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1. Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (By similarity).
Cellular Location Nucleus.
Tissue Location Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes
Research Areas
Citations (0)

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The protein encoded by this gene is a DNA-bindingtranscription factor and is a member of the NR1 subfamily ofnuclear hormone receptors. The specific functions of this proteinare not known; however, studies of a similar gene in mice haveshown that this gene may be essential for lymphoid organogenesisand may play an important regulatory role in thymopoiesis. Inaddition, studies in mice suggest that the protein encoded by thisgene may inhibit the expression of Fas ligand and IL2. Twotranscript variants encoding different isoforms have been found forthis gene.


Wang, Y., et al. Biochim. Biophys. Acta 1801(8):917-923(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Burgler, S., et al. J. Immunol. 184(11):6161-6169(2010)Jin, L., et al. Mol. Endocrinol. 24(5):923-929(2010)Wang, W.J., et al. J. Reprod. Immunol. 84(2):164-170(2010)

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$ 80.00
Cat# BP13786c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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