|Other Names||Rab GDP dissociation inhibitor beta, Rab GDI beta, Guanosine diphosphate dissociation inhibitor 2, GDI-2, GDI2, RABGDIB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13787c was selected from the Center region of GDI2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
GDP dissociation inhibitors are proteins that regulate theGDP-GTP exchange reaction of members of the rab family, smallGTP-binding proteins of the ras superfamily, that are involved invesicular trafficking of molecules between cellular organelles.GDIs slow the rate of dissociation of GDP from rab proteins andrelease GDP from membrane-bound rabs. GDI2 is ubiquitouslyexpressed. The GDI2 gene contains many repetitive elementsindicating that it may be prone to inversion/deletionrearrangements. Alternative splicing results in multiple transcriptvariants encoding distinct isoforms.
Rikova, K., et al. Cell 131(6):1190-1203(2007)Sun, Z.L., et al. Biochim. Biophys. Acta 1774(6):764-771(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Shin, B.K., et al. J. Biol. Chem. 278(9):7607-7616(2003)
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