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RAB1B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H0U4 |
|---|---|
| Clone Names | 100318142 |
| Gene ID | 81876 |
|---|---|
| Other Names | Ras-related protein Rab-1B, RAB1B |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13810b was selected from the C-term region of RAB1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RAB1B |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). |
| Cellular Location | Cytoplasm. Membrane; Lipid-anchor; Cytoplasmic side. Preautophagosomal structure membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P10536}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments (PubMed:11389151). In the GDP-form, colocalizes with GDI in the cytoplasm (PubMed:11389151). Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri- Golgi region (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000269|PubMed:11389151} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the RAB protein family, such as RAB1B, are lowmolecular mass monomeric GTPases localized on the cytoplasmicsurfaces of distinct membrane-bound organelles. RAB1B functions inthe early secretory pathway and is essential for vesicle transportbetween the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997[PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[suppliedby OMIM].
References
Yamayoshi, S., et al. J. Virol. 84(9):4816-4820(2010)Machner, M.P., et al. Science 318(5852):974-977(2007)Monetta, P., et al. Mol. Biol. Cell 18(7):2400-2410(2007)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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