|Other Names||E3 ubiquitin-protein ligase MARCH11, 632-, Membrane-associated RING finger protein 11, Membrane-associated RING-CH protein XI, MARCH-XI, MARCH11|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13811b was selected from the C-term region of MARCH11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity).|
|Cellular Location||Cytoplasmic vesicle membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
MARCH11 is a member of the MARCH family of membrane-boundE3 ubiquitin ligases (EC 126.96.36.199). These enzymes add ubiquitin(see MIM 191339) to target lysines in substrate proteins, therebysignaling their intracellular transport. March11 appears to have arole in ubiquitin-mediated protein sorting in the trans-Golginetwork (TGN)-multivesicular body (MVB) transport pathway (Morokumaet al., 2007 [PubMed 17604280]).
Rose, J. Phd, et al. Mol. Med. (2010) In press :Morokuma, Y., et al. J. Biol. Chem. 282(34):24806-24815(2007)
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