|Other Names||DNA repair protein complementing XP-A cells, Xeroderma pigmentosum group A-complementing protein, XPA, XPAC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13836b was selected from the C-term region of XPA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.|
|Tissue Location||Expressed in various cell lines and in skin fibroblasts.|
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This gene encodes a zinc finger protein involved in DNAexcision repair. The encoded protein is part of the NER (nucleotideexcision repair) complext which is responsible for repair of UVradiation-induced photoproducts and DNA adducts induced by chemicalcarcinogens. Mutations in this gene are associated with xerodermapigmentosum complementation group A. Alternatively splicedtranscript variants have been found for this gene. [provided byRefSeq].
Palli, D., et al. Mutagenesis 25(6):569-575(2010)Fan, W., et al. Mol. Cell 39(2):247-258(2010)Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :Hsieh, Y.Y., et al. Anticancer Res. 30(6):2203-2208(2010)Jelonek, K., et al. J. Appl. Genet. 51(3):343-352(2010)
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