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XPA Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23025 |
|---|---|
| Clone Names | 100427131 |
| Gene ID | 7507 |
|---|---|
| Other Names | DNA repair protein complementing XP-A cells, Xeroderma pigmentosum group A-complementing protein, XPA, XPAC |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13836b was selected from the C-term region of XPA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | XPA |
|---|---|
| Synonyms | XPAC |
| Function | Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. |
| Cellular Location | Nucleus |
| Tissue Location | Expressed in various cell lines and in skin fibroblasts. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a zinc finger protein involved in DNAexcision repair. The encoded protein is part of the NER (nucleotideexcision repair) complext which is responsible for repair of UVradiation-induced photoproducts and DNA adducts induced by chemicalcarcinogens. Mutations in this gene are associated with xerodermapigmentosum complementation group A. Alternatively splicedtranscript variants have been found for this gene. [provided byRefSeq].
References
Palli, D., et al. Mutagenesis 25(6):569-575(2010)Fan, W., et al. Mol. Cell 39(2):247-258(2010)Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :Hsieh, Y.Y., et al. Anticancer Res. 30(6):2203-2208(2010)Jelonek, K., et al. J. Appl. Genet. 51(3):343-352(2010)
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