|Other Names||Troponin C, slow skeletal and cardiac muscles, TN-C, TNNC1, TNNC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13841a was selected from the N-term region of TNNC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.|
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Troponin is a central regulatory protein of striatedmuscle contraction, and together with tropomyosin, is located onthe actin filament. Troponin consists of 3 subunits: TnI, which isthe inhibitor of actomyosin ATPase; TnT, which contains the bindingsite for tropomyosin; and TnC, the protein encoded by this gene.The binding of calcium to TnC abolishes the inhibitory action ofTnI, thus allowing the interaction of actin with myosin, thehydrolysis of ATP, and the generation of tension. Mutations in thisgene are associated with cardiomyopathy dilated type 1Z. [providedby RefSeq].
Parvatiyar, M.S., et al. J. Biol. Chem. 285(36):27785-27797(2010)Swindle, N., et al. Biochemistry 49(23):4813-4820(2010)Dweck, D., et al. J. Biol. Chem. 285(23):17371-17379(2010)Bates, K.J., et al. Clin. Chem. 56(6):952-958(2010)Hershberger, R.E., et al. Circ Cardiovasc Genet 3(2):155-161(2010)
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