RAB6B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NRW1 |
---|---|
Clone Names | 100405187 |
Gene ID | 51560 |
---|---|
Other Names | Ras-related protein Rab-6B, RAB6B |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13850b was selected from the C-term region of RAB6B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RAB6B (HGNC:14902) |
---|---|
Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (Probable). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). |
Cellular Location | Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum-Golgi intermediate compartment Cytoplasmic vesicle. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules |
Tissue Location | Predominantly expressed in brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
RAB6B seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Wanschers, B., et al. Cell Motil. Cytoskeleton 65(3):183-196(2008)Wanschers, B.F., et al. Exp. Cell Res. 313(16):3408-3420(2007)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Garcia-Saez, I., et al. Acta Crystallogr. D Biol. Crystallogr. 62 (PT 7), 725-733 (2006) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.