|Other Names||C-C chemokine receptor type 9, C-C CKR-9, CC-CKR-9, CCR-9, G-protein coupled receptor 28, GPR-9-6, CDw199, CCR9, GPR28|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13854b was selected from the C-term region of CCR9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highly expressed in the thymus and low in lymph nodes and spleen.|
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The protein encoded by this gene is a member of the betachemokine receptor family. It is predicted to be a seventransmembrane protein similar to G protein-coupled receptors.Chemokines and their receptors are key regulators of the thymocytesmigration and maturation in normal and inflammation conditions. Thespecific ligand of this receptor is CCL25. It has been found thatthis gene is differentially expressed by T lymphocytes of smallintestine and colon, suggested a role in the thymocytes recruitmentand development that may permit functional specialization of immuneresponses in different segment of the gastrointestinal tract. Thisgene is mapped to the chemokine receptor gene cluster region. Twoalternatively spliced transcript variants have been described.
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Wang, Y., et al. Cell. Mol. Immunol. 7(1):51-60(2010)
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