|Other Names||Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1, Eptotermin alfa, BMP7, OP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13859b was selected from the C-term region of BMP7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.|
|Tissue Location||Expressed in the kidney and bladder. Lower levels seen in the brain|
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Provided below are standard protocols that you may find useful for product applications.
The bone morphogenetic proteins (BMPs) are a family ofsecreted signaling molecules that can induce ectopic bone growth.Many BMPs are part of the transforming growth factor-beta (TGFB)superfamily. BMPs were originally identified by an ability ofdemineralized bone extract to induce endochondral osteogenesis invivo in an extraskeletal site. Based on its expression early inembryogenesis, the BMP encoded by this gene has a proposed role inearly development and possible bone inductive activity. [providedby RefSeq].
Hwang, C.J., et al. J Neurosurg Spine 13(4):484-493(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Jonigk, D., et al. Virchows Arch. 457(3):369-380(2010)Pegorier, S., et al. Respir. Res. 11, 85 (2010) :
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