|Other Names||Guanylin, Guanylate cyclase activator 2A, Guanylate cyclase-activating protein 1, Guanylate cyclase-activating protein I, GCAP-I, HMW-guanylin, Guanylin, GUCA2A, GUCA2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13866c was selected from the Center region of GUCA2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.|
|Tissue Location||Highly expressed in ileum and colon. Found in plasma|
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Provided below are standard protocols that you may find useful for product applications.
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
Dell'Orco, D., et al. Cell. Mol. Life Sci. 67(6):973-984(2010)Chen, Y.B., et al. Zhonghua Wei Chang Wai Ke Za Zhi 12(5):515-517(2009)Albano, F., et al. Pediatr. Res. 58(1):159-163(2005)Sindic, A., et al. Kidney Int. 67(4):1420-1427(2005)Kulaksiz, H., et al. Gastroenterology 126(3):732-740(2004)
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