|Other Names||Neuropeptide FF receptor 2, G-protein coupled receptor 74, G-protein coupled receptor HLWAR77, Neuropeptide G-protein coupled receptor, NPFFR2, GPR74, NPFF2, NPGPR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13867a was selected from the N-term region of NPFFR2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR74, NPFF2, NPGPR|
|Function||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower levels, in kidney, liver, lung and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a subfamily ofG-protein-coupled neuropeptide receptors. This protein is activatedby the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and mayfunction in pain modulation and regulation of the opioid system.Alternative splicing results in multiple transcript variants.
Talmont, F., et al. Peptides 31(2):215-220(2010)Goncharuk, V., et al. Peptides 29(9):1544-1553(2008)Dahlman, I., et al. Am. J. Hum. Genet. 80(6):1115-1124(2007)Anko, M.L., et al. FEBS Lett. 580(30):6955-6960(2006)Dowal, L., et al. J. Biol. Chem. 281(33):23999-24014(2006)
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