|Other Names||Roundabout homolog 2, ROBO2, KIAA1568|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13883a was selected from the N-term region of ROBO2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the ROBO family, part of theimmunoglobulin superfamily proteins that are highly conserved fromfly to human. The encoded protein is a receptor for SLIT2,molecules known to function in axon guidance and cell migration.Defects in this gene are the cause of vesicoureteral reflux type 2.Alternatively spliced transcript variants encoding differentisoforms have been described for this gene.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Yue, Y., et al. Genomics 88(6):772-778(2006)Hivert, B., et al. Mol. Cell. Neurosci. 21(4):534-545(2002)Kidd, T., et al. Cell 92(2):205-215(1998)
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