|Other Names||Sodium/potassium/calcium exchanger 2, Na(+)/K(+)/Ca(2+)-exchange protein 2, Retinal cone Na-Ca+K exchanger, Solute carrier family 24 member 2, SLC24A2, NCKX2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13886c was selected from the Center region of SLC24A2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The outer segment of retinal rod and cone photoreceptorscontains electrogenic sodium-calcium exchangers which mediate alight-induced decrease in free calcium concentration. This functionin cones is performed by SLC24A2 (Prinsen et al., 2000 [PubMed10662833]).
Altimimi, H.F., et al. J. Biol. Chem. 285(20):15245-15255(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Kim, S.H., et al. Clin. Exp. Allergy 39(2):203-212(2009)Ginger, R.S., et al. J. Biol. Chem. 283(9):5486-5495(2008)Altimimi, H.F., et al. J. Biol. Chem. 282(6):3720-3729(2007)
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