NRBP1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UHY1 |
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Clone Names | 100430235 |
Gene ID | 29959 |
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Other Names | Nuclear receptor-binding protein, NRBP1, BCON3 {ECO:0000312|EMBL:AAF219671}, NRBP |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13894a was selected from the N-term region of NRBP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NRBP1 |
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Synonyms | BCON3 {ECO:0000312|EMBL:AAF21967.1}, NRB |
Function | Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397). |
Cellular Location | Cytoplasm, cell cortex. Endomembrane system. Cell projection, lamellipodium. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia |
Tissue Location | Ubiquitously expressed in all tissues examined with high levels in the testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
NRBP1 may play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Wang, H., et al. FEBS Lett. 580(25):6015-6021(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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