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TOP1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P11387
Clone Names 100430241
Peptide ID 100430241
Additional Information
Gene ID 7150
Other Names DNA topoisomerase 1, DNA topoisomerase I, TOP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13897a was selected from the N-term region of TOP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TOP1
Function Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.
Cellular Location Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both nucleoplasm and nucleoli
Tissue Location Endothelial cells.
Research Areas
Citations (0)

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This gene encodes a DNA topoisomerase, an enzyme thatcontrols and alters the topologic states of DNA duringtranscription. This enzyme catalyzes the transient breaking andrejoining of a single strand of DNA which allows the strands topass through one another, thus altering the topology of DNA. Thisgene is localized to chromosome 20 and has pseudogenes which resideon chromosomes 1 and 22.


Kjeldsen, E., et al. Anticancer Res. 30(9):3257-3265(2010)Reinhold, W.C., et al. Cancer Res. 70(6):2191-2203(2010)Tesauro, C., et al. Biochem. J. 425(3):531-539(2010)Ballot, C., et al. Mol. Cancer Ther. 8(12):3307-3317(2009)Lebedeva, N.A., et al. Biochemistry Mosc. 74(11):1278-1284(2009)

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$ 80.00
Cat# BP13897a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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