Mouse Mylk3 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q3UIZ8 |
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Clone Names | 110316281 |
Gene ID | 213435 |
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Other Names | Myosin light chain kinase 3, Cardiac-MyBP-C-associated Ca/CaM kinase, Cardiac-MLCK, Mylk3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13923a was selected from the N-term region of Mouse Mylk3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Mylk3 |
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Function | Kinase that phosphorylates MYL2 in vitro (PubMed:18202317, PubMed:17885681). Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317). Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). |
Cellular Location | Cytoplasm. |
Tissue Location | Restricted to cardiomyocytes (at protein level). Down-regulated in heart after experimental myocardial infarction at the protein level; no significant changes at the mRNA level |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mylk3 may play a role in smooth muscle contraction (By similarity).
References
White, R.A., et al. Blood Cells Mol. Dis. 43(2):141-148(2009)Chan, J.Y., et al. Circ. Res. 102(5):571-580(2008)Kim, B.J., et al. Can. J. Physiol. Pharmacol. 85(12):1254-1262(2007)Seguchi, O., et al. J. Clin. Invest. 117(10):2812-2824(2007)Choi, Y.O., et al. Exp. Mol. Med. 38(2):180-189(2006)
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