|Other Names||Myosin light chain kinase 3, Cardiac-MyBP-C-associated Ca/CaM kinase, Cardiac-MLCK, Mylk3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13923a was selected from the N-term region of Mouse Mylk3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Kinase that phosphorylates MYL2 in vitro. Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317). Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility.|
|Tissue Location||Restricted to cardiomyocytes (at protein level). Down-regulated in heart after experimental myocardial infarction at the protein level; no significant changes at the mRNA level.|
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Provided below are standard protocols that you may find useful for product applications.
Mylk3 may play a role in smooth muscle contraction (By similarity).
White, R.A., et al. Blood Cells Mol. Dis. 43(2):141-148(2009)Chan, J.Y., et al. Circ. Res. 102(5):571-580(2008)Kim, B.J., et al. Can. J. Physiol. Pharmacol. 85(12):1254-1262(2007)Seguchi, O., et al. J. Clin. Invest. 117(10):2812-2824(2007)Choi, Y.O., et al. Exp. Mol. Med. 38(2):180-189(2006)
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