|Other Names||Cytochrome P450 4F22, 11414-, CYP4F22|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13937b was selected from the C-term region of CYP4F22. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein Microsome membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.This gene is part of a cluster of cytochrome P450 genes onchromosome 19 and encodes an enzyme thought to play a role in the12(R)-lipoxygenase pathway. Mutations in this gene are the cause ofichthyosis lamellar type 3.
Elias, P.M., et al. J. Lipid Res. 49(4):697-714(2008)Lefevre, C., et al. Hum. Mol. Genet. 15(5):767-776(2006)Nelson, D.R., et al. Pharmacogenetics 14(1):1-18(2004)Fischer, J., et al. Am. J. Hum. Genet. 66(3):904-913(2000)
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