DPAGT1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H3H5 |
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Clone Names | 100318267 |
Gene ID | 1798 |
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Other Names | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, GlcNAc-1-P transferase, G1PT, GPT, N-acetylglucosamine-1-phosphate transferase, DPAGT1, DPAGT2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13970a was selected from the N-term region of DPAGT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GPT |
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Function | Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol. |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is an enzyme thatcatalyzes the first step in the dolichol-linked oligosaccharidepathway for glycoprotein biosynthesis. This enzyme belongs to theglycosyltransferase family 4. This protein is an integral membraneprotein of the endoplasmic reticulum. The congenital disorder ofglycosylation type Ij is caused by mutation in the gene encodingthis enzyme.
References
Sengupta, P.K., et al. J. Biol. Chem. 285(41):31164-31173(2010)Nita-Lazar, M., et al. Cancer Res. 69(14):5673-5680(2009)Bretthauer, R.K. Curr Drug Targets 10(6):477-482(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Wu, X., et al. Hum. Mutat. 22(2):144-150(2003)
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