|Other Names||UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, GlcNAc-1-P transferase, G1PT, GPT, N-acetylglucosamine-1-phosphate transferase, DPAGT1, DPAGT2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13970a was selected from the N-term region of DPAGT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an enzyme thatcatalyzes the first step in the dolichol-linked oligosaccharidepathway for glycoprotein biosynthesis. This enzyme belongs to theglycosyltransferase family 4. This protein is an integral membraneprotein of the endoplasmic reticulum. The congenital disorder ofglycosylation type Ij is caused by mutation in the gene encodingthis enzyme.
Sengupta, P.K., et al. J. Biol. Chem. 285(41):31164-31173(2010)Nita-Lazar, M., et al. Cancer Res. 69(14):5673-5680(2009)Bretthauer, R.K. Curr Drug Targets 10(6):477-482(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Wu, X., et al. Hum. Mutat. 22(2):144-150(2003)
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