|Other Names||Scavenger receptor cysteine-rich type 1 protein M160, CD163 antigen-like 1, CD163b, CD163L1, CD163B, M160|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13979b was selected from the C-term region of CD163L1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.|
|Tissue Location||Isoform 1 is highly expressed in the spleen, lymph nodes, thymus, and fetal liver and weakly expressed in bone marrow and no expression was found in peripheral blood leukocytes Isoform 1 expression is restricted to the monocyte and macrophage cell lines. Isoform 2 is only expressed in spleen|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the scavenger receptorcysteine-rich (SRCR) superfamily. Members of this family aresecreted or membrane-anchored proteins mainly found in cellsassociated with the immune system. The SRCR family is defined by a100-110 amino acid SRCR domain, which may mediate protein-proteininteraction and ligand binding. The encoded protein contains twelveSRCR domains, a transmembrane region and a cytoplasmic domain.Alternatively spliced transcript variants encoding differentisoforms have been described but their full-length nature has notbeen determined.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Van Gorp, H., et al. J. Virol. 84(6):3101-3105(2010)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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