|Other Names||Protein unc-45 homolog B, Unc-45B, SMUNC45, UNC45B, CMYA4, UNC45|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13982a was selected from the N-term region of UNC45B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development.|
|Cellular Location||Cytoplasm, cytosol.|
|Tissue Location||Expressed in eye lens tissues.|
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Provided below are standard protocols that you may find useful for product applications.
UNC45B plays a role in myoblast fusion and sarcomereorganization (Price et al., 2002 [PubMed 12356907]).[supplied byOMIM].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Price, M.G., et al. J. Cell. Sci. 115 (PT 21), 4013-4023 (2002) :
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