HEXIM1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O94992 |
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Clone Names | 100427223 |
Gene ID | 10614 |
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Other Names | Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13992a was selected from the N-term region of HEXIM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HEXIM1 |
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Synonyms | CLP1, EDG1, HIS1, MAQ1 |
Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). |
Cellular Location | Nucleus. Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050) |
Tissue Location | Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Expression of this gene is induced byhexamethylene-bis-acetamide in vascular smooth muscle cells. Thisgene has no introns.
References
Dow, E.C., et al. J. Cell. Physiol. 224(1):84-93(2010)Ogba, N., et al. Oncogene 29(25):3639-3649(2010)Schonichen, A., et al. Biochemistry 49(14):3083-3091(2010)Czudnochowski, N., et al. J. Mol. Biol. 395(1):28-41(2010)Krueger, B.J., et al. PLoS ONE 5 (8), E12335 (2010) :
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