|Other Names||Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13992a was selected from the N-term region of HEXIM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLP1, EDG1, HIS1, MAQ1|
|Function||Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).|
|Cellular Location||Nucleus Cytoplasm. Note=Binds alpha-importin and is mostly nuclear (PubMed:16362050)|
|Tissue Location||Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed Expressed in endocrine tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Expression of this gene is induced byhexamethylene-bis-acetamide in vascular smooth muscle cells. Thisgene has no introns.
Dow, E.C., et al. J. Cell. Physiol. 224(1):84-93(2010)Ogba, N., et al. Oncogene 29(25):3639-3649(2010)Schonichen, A., et al. Biochemistry 49(14):3083-3091(2010)Czudnochowski, N., et al. J. Mol. Biol. 395(1):28-41(2010)Krueger, B.J., et al. PLoS ONE 5 (8), E12335 (2010) :
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