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SLC18A3 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16572 |
|---|---|
| Clone Names | 100430164 |
| Gene ID | 6572 |
|---|---|
| Other Names | Vesicular acetylcholine transporter, VAChT, Solute carrier family 18 member 3, SLC18A3, VACHT |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14010c was selected from the Center region of SLC18A3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC18A3 |
|---|---|
| Synonyms | VACHT |
| Function | Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis (PubMed:8910293, PubMed:20225888) (By similarity). Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern (By similarity). Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation (By similarity). Can transport serotonin. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q62666}; Multi-pass membrane protein |
| Tissue Location | Peripheral and central cholinergic nervous systems. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the vesicular amine transporterfamily. The encoded transmembrane protein transports acetylcholineinto secretory vesicles for release into the extracellular space.Acetylcholine transport utilizes a proton gradient established by avacuolar ATPase. This gene is located within the first intron ofthe choline acetyltransferase gene.
References
Khare, P., et al. J. Neurochem. 115(4):984-993(2010)Harrington, A.M., et al. Cell Tissue Res. 341(1):33-48(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Khare, P., et al. Biochemistry 48(38):8965-8975(2009)
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