CDH4 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P55283 |
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Clone Names | 70730021 |
Gene ID | 1002 |
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Other Names | Cadherin-4, Retinal cadherin, R-CAD, R-cadherin, CDH4 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1401a was selected from the N-term region of human CDH4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CDH4 |
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Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
Tissue Location | Expressed mainly in brain but also found in other tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
CDH4 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.
References
Miotto,E., Cancer Res. 64 (22), 8156-8159 (2004)Johnson,E., J. Biol. Chem. 279 (30), 31041-31049 (2004)Kitagawa,M., Biochem. Biophys. Res. Commun. 271 (2), 358-363 (2000)
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