|Other Names||Transcription factor HES-1, Class B basic helix-loop-helix protein 39, bHLHb39, Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, hHL, HES1, BHLHB39, HL, HRY|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14023a was selected from the N-term region of HES1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BHLHB39, HL, HRY|
|Function||Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.|
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Provided below are standard protocols that you may find useful for product applications.
This protein belongs to the basic helix-loop-helix familyof transcription factors. It is a transcriptional repressor ofgenes that require a bHLH protein for their transcription. Theprotein has a particular type of basic domain that contains a helixinterrupting protein that binds to the N-box rather than thecanonical E-box.
Espinosa, L., et al. Cancer Cell 18(3):268-281(2010)Wang, X., et al. J. Cancer Res. Clin. Oncol. 136(7):989-996(2010)Sang, L., et al. Trends Mol Med 16(1):17-26(2010)Duan, L., et al. Front Biosci (Elite Ed) 2, 1065-1072 (2010) :Coad, R.A., et al. Biochem. Cell Biol. 87(6):975-987(2009)
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