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HES1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q14469
Clone Names 100430230
Peptide ID 100430230
Additional Information
Gene ID 3280
Other Names Transcription factor HES-1, Class B basic helix-loop-helix protein 39, bHLHb39, Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, hHL, HES1, BHLHB39, HL, HRY
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14023a was selected from the N-term region of HES1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HES1
Synonyms BHLHB39, HL, HRY
Function Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Cellular Location Nucleus.
Research Areas
Citations (0)

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This protein belongs to the basic helix-loop-helix familyof transcription factors. It is a transcriptional repressor ofgenes that require a bHLH protein for their transcription. Theprotein has a particular type of basic domain that contains a helixinterrupting protein that binds to the N-box rather than thecanonical E-box.


Espinosa, L., et al. Cancer Cell 18(3):268-281(2010)Wang, X., et al. J. Cancer Res. Clin. Oncol. 136(7):989-996(2010)Sang, L., et al. Trends Mol Med 16(1):17-26(2010)Duan, L., et al. Front Biosci (Elite Ed) 2, 1065-1072 (2010) :Coad, R.A., et al. Biochem. Cell Biol. 87(6):975-987(2009)

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$ 80.00
Cat# BP14023a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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