|Other Names||Probable ATP-dependent RNA helicase DDX4, DEAD box protein 4, Vasa homolog, DDX4, VASA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1403b was selected from the C-term region of human DDX4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in germ cell development. May play a role in sperm motility.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region|
|Tissue Location||Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.|
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Provided below are standard protocols that you may find useful for product applications.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.
Guo,X., Asian J. Androl. 9 (3), 339-344 (2007)Zeeman,A.M., Lab. Invest. 82 (2), 159-166 (2002)Castrillon,D.H., Proc. Natl. Acad. Sci. U.S.A. 97 (17), 9585-9590 (2000)
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