|Other Names||Homeobox protein DLX-4, Beta protein 1, Homeobox protein DLX-7, Homeobox protein DLX-8, DLX4, BP1, DLX7, DLX8, DLX9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14046c was selected from the Center region of DLX4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BP1, DLX7, DLX8, DLX9|
|Function||May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.|
|Tissue Location||Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.|
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Many vertebrate homeo box-containing genes have beenidentified on the basis of their sequence similarity withDrosophila developmental genes. Members of the Dlx gene familycontain a homeobox that is related to that of Distal-less (Dll), agene expressed in the head and limbs of the developing fruit fly.The Distal-less (Dlx) family of genes comprises at least 6different members, DLX1-DLX6. The DLX proteins are postulated toplay a role in forebrain and craniofacial development. Threetranscript variants have been described for this gene, however, thefull length nature of one variant has not been described. Studiesof the two splice variants revealed that one encoded isoformfunctions as a repressor of the beta-globin gene while the otherisoform lacks that function.
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Schwartz, A.M., et al. Mod. Pathol. 22(1):1-6(2009)Man, Y.G., et al. Cancer Biomark 5(1):9-17(2009)Cavalli, L.R., et al. Cancer Genet. Cytogenet. 187(1):19-24(2008)Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
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