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TRPV2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y5S1 |
|---|---|
| Clone Names | 100507024 |
| Gene ID | 51393 |
|---|---|
| Other Names | Transient receptor potential cation channel subfamily V member 2, TrpV2, Osm-9-like TRP channel 2, OTRPC2, Vanilloid receptor-like protein 1, VRL-1, TRPV2, VRL |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14049a was selected from the N-term region of TRPV2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRPV2 |
|---|---|
| Synonyms | VRL |
| Function | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF- I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an ion channel that is activated by hightemperatures above 52 degrees Celsius. The protein may be involvedin transduction of high-temperature heat responses in sensoryganglia. It is thought that in other tissues the channel may beactivated by stimuli other than heat.
References
Mercado, J., et al. J. Neurosci. 30(40):13338-13347(2010)Nabissi, M., et al. Carcinogenesis 31(5):794-803(2010)Monet, M., et al. Cancer Res. 70(3):1225-1235(2010)Liu, G., et al. Cancer Genet. Cytogenet. 197(1):54-59(2010)Saunders, C.I., et al. Biochim. Biophys. Acta 1792(10):1019-1026(2009)
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