|Other Names||Transient receptor potential cation channel subfamily V member 2, TrpV2, Osm-9-like TRP channel 2, OTRPC2, Vanilloid receptor-like protein 1, VRL-1, TRPV2, VRL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14049a was selected from the N-term region of TRPV2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an ion channel that is activated by hightemperatures above 52 degrees Celsius. The protein may be involvedin transduction of high-temperature heat responses in sensoryganglia. It is thought that in other tissues the channel may beactivated by stimuli other than heat.
Mercado, J., et al. J. Neurosci. 30(40):13338-13347(2010)Nabissi, M., et al. Carcinogenesis 31(5):794-803(2010)Monet, M., et al. Cancer Res. 70(3):1225-1235(2010)Liu, G., et al. Cancer Genet. Cytogenet. 197(1):54-59(2010)Saunders, C.I., et al. Biochim. Biophys. Acta 1792(10):1019-1026(2009)
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