|Other Names||Vasopressin V1b receptor, V1bR, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Vasopressin V3 receptor, AVPR1B, AVPR3, VPR3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14050b was selected from the C-term region of AVPR1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene acts as receptor forarginine vasopressin. This receptor belongs to the subfamily ofG-protein coupled receptors which includes AVPR1A, V2R and OXTreceptors. Its activity is mediated by G proteins which stimulate aphosphatidylinositol-calcium second messenger system. The receptoris primarily located in the anterior pituitary, where it stimulatesACTH release. It is expressed at high levels in ACTH-secretingpituitary adenomas as well as in bronchial carcinoids responsiblefor the ectopic ACTH syndrome. A spliced antisense transcript ofthis gene has been reported but its function is not known.
van West, D., et al. Psychiatry Res 179(1):64-68(2010)Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010)Bosker, F.J., et al. Mol. Psychiatry (2010) In press :van West, D., et al. Psychiatr. Genet. 19(2):102-103(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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