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BAG2 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O95816
Clone Names 100507034
Peptide ID 100507034
Additional Information
Gene ID 9532
Other Names BAG family molecular chaperone regulator 2, BAG-2, Bcl-2-associated athanogene 2, BAG2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14053b was selected from the C-term region of BAG2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAG2
Function Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.
Research Areas
Citations (0)

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BAG proteins compete with Hip for binding to theHsc70/Hsp70 ATPase domain and promote substrate release. All theBAG proteins have an approximately 45-amino acid BAG domain nearthe C terminus but differ markedly in their N-terminal regions. Thepredicted BAG2 protein contains 211 amino acids. The BAG domains ofBAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPasedomain in vitro and in mammalian cells. All 3 proteins bind withhigh affinity to the ATPase domain of Hsc70 and inhibit itschaperone activity in a Hip-repressible manner. [provided byRefSeq].


Arndt, V., et al. Mol. Biol. Cell 16(12):5891-5900(2005)Dai, Q., et al. J. Biol. Chem. 280(46):38673-38681(2005)Ueda, K., et al. J. Biol. Chem. 279(40):41815-41821(2004)Ueda, K., et al. J. Biol. Chem. 279(40):41815-41821(2004)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)

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$ 80.00
Cat# BP14053b
Availability: In Stock
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