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ADAM11 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75078 |
|---|---|
| Clone Names | 100507070 |
| Gene ID | 4185 |
|---|---|
| Other Names | Disintegrin and metalloproteinase domain-containing protein 11, ADAM 11, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein, MDC, ADAM11, MDC |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14066a was selected from the N-term region of ADAM11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ADAM11 |
|---|---|
| Synonyms | MDC |
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress (By similarity). Plays a role in spatial learning and motor coordination (By similarity). Involved in the nociceptive pain response to chemical-derived stimulation (By similarity). |
| Cellular Location | Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9R1V4}; Single-pass type I membrane protein Perikaryon {ECO:0000250|UniProtKB:Q9R1V4}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V4}. Note=Localizes to basket cell terminals and pinceaux. {ECO:0000250|UniProtKB:Q9R1V4} |
| Tissue Location | Expressed predominantly in brain. Slightly detected or not at all in other tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the ADAM (a disintegrin andmetalloprotease) protein family. Members of this family aremembrane-anchored proteins structurally related to snake venomdisintegrins, and have been implicated in a variety of biologicalprocesses involving cell-cell and cell-matrix interactions,including fertilization, muscle development, and neurogenesis. Thisgene represents a candidate tumor supressor gene for human breastcancer based on its location within a minimal region of chromosome17q21 previously defined by tumor deletion mapping. [provided byRefSeq].
References
Fu, G.K., et al. Genomics 84(1):205-210(2004)Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :Shea, S.H., et al. Behav. Genet. 31(2):231-239(2001)Sagane, K., et al. Biochem. J. 334 (PT 1), 93-98 (1998) :Wolfsberg, T.G., et al. J. Cell Biol. 131(2):275-278(1995)
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