|Other Names||Disintegrin and metalloproteinase domain-containing protein 11, ADAM 11, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein, MDC, ADAM11, MDC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14066a was selected from the N-term region of ADAM11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed predominantly in brain. Slightly detected or not at all in other tissues|
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This gene encodes a member of the ADAM (a disintegrin andmetalloprotease) protein family. Members of this family aremembrane-anchored proteins structurally related to snake venomdisintegrins, and have been implicated in a variety of biologicalprocesses involving cell-cell and cell-matrix interactions,including fertilization, muscle development, and neurogenesis. Thisgene represents a candidate tumor supressor gene for human breastcancer based on its location within a minimal region of chromosome17q21 previously defined by tumor deletion mapping. [provided byRefSeq].
Fu, G.K., et al. Genomics 84(1):205-210(2004)Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :Shea, S.H., et al. Behav. Genet. 31(2):231-239(2001)Sagane, K., et al. Biochem. J. 334 (PT 1), 93-98 (1998) :Wolfsberg, T.G., et al. J. Cell Biol. 131(2):275-278(1995)
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