|Other Names||Cysteine and glycine-rich protein 2, Cysteine-rich protein 2, CRP2, LIM domain only protein 5, LMO-5, Smooth muscle cell LIM protein, SmLIM, CSRP2, LMO5, SMLIM|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14068c was selected from the Center region of CSRP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.|
|Tissue Location||Highly expressed in the aorta, but not in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
CSRP2 is a member of the CSRP family of genes, encoding agroup of LIM domain proteins, which may be involved in regulatoryprocesses important for development and cellular differentiation.CRP2 contains two copies of the cysteine-rich amino acid sequencemotif (LIM) with putative zinc-binding activity, and may beinvolved in regulating ordered cell growth. Other genes in thefamily include CSRP1 and CSRP3.
Stearns, M.E., et al. Mol. Cancer Res. 1(9):631-642(2003)Wang, M., et al. Cancer Biol. Ther. 1(5):556-563(2002)Weiskirchen, R., et al. Biochem. J. 359 (PT 3), 485-496 (2001) :Weiskirchen, R., et al. Biochem. Biophys. Res. Commun. 274(3):655-663(2000)Weiskirchen, R., et al. Genomics 44(1):83-93(1997)
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