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BECN1 Antibody (N-term T72) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q14457
Clone Names 70226192
Peptide ID 70226192
Additional Information
Gene ID 8678
Other Names Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, BECN1, GT197
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14089a was selected from the N-term T72 region of BECN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BECN1
Synonyms GT197
Function Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3- C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19713971, ECO:0000269|PubMed:21364619}. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Endosome {ECO:0000250|UniProtKB:O88597}. Cytoplasmic vesicle, autophagosome. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity) {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19050071} Beclin-1-C 37 kDa: Mitochondrion {ECO:0000250|UniProtKB:O88597}
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

Beclin-1 participates in the regulation of autophagy andhas an important role in development, tumorigenesis, andneurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[suppliedby OMIM].

References

Koukourakis, M.I., et al. Br. J. Cancer 103(8):1209-1214(2010)Jaeger, P.A., et al. Arch. Neurol. 67(10):1181-1184(2010)Metzger, S., et al. Hum. Genet. 128(4):453-459(2010)Oberstein, A., et al. J. Biol. Chem. 282(17):13123-13132(2007)Furuya, N., et al. Autophagy 1(1):46-52(2005)

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$ 80.00
Cat# BP14089a
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