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SHB Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q15464
Clone Names 70716060
Peptide ID 70716060
Additional Information
Gene ID 6461
Other Names SH2 domain-containing adapter protein B, SHB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1408c was selected from the Center region of human SHB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHB
Function Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

SHB is an adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. It may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. It may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades, and may also regulate IRS1 and IRS2 signaling in insulin-producing cells.

References

Kriz,V., J. Biol. Chem. 281 (45), 34484-34491 (2006)Saldeen,J., Biochem. Biophys. Res. Commun. 344 (2), 517-524 (2006)Zhang,Y., J. Cell. Sci. 119 (PT 8), 1666-1676 (2006)

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$ 80.00
Cat# BP1408c
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