|Other Names||Carboxypeptidase O, CPO, 3417-, CPO|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14095a was selected from the N-term region of CPO. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C- terminal hydrophobic amino acids, with a preference for small residues over large residues.|
|Cellular Location||Apical cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Detected in enterocytes of the ileum.|
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Provided below are standard protocols that you may find useful for product applications.
Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues (By similarity).
Hillier, L.W., et al. Nature 434(7034):724-731(2005)Wei, S., et al. J. Biol. Chem. 277(17):14954-14964(2002)
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