|Other Names||Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, LMO-2, T-cell translocation protein 2, LMO2, RBTN2, RBTNL1, RHOM2, TTG2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14102a was selected from the N-term region of LMO2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||RBTN2, RBTNL1, RHOM2, TTG2|
|Function||Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.|
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Provided below are standard protocols that you may find useful for product applications.
LMO2 encodes a cysteine-rich, two LIM-domain protein thatis required for yolk sac erythropoiesis. The LMO2 protein has acentral and crucial role in hematopoietic development and is highlyconserved. The LMO2 transcription start site is locatedapproximately 25 kb downstream from the 11p13 T-cell translocationcluster (11p13 ttc), where a number T-cell acute lymphoblasticleukemia-specific translocations occur. Alternative splicingresults in multiple transcript variants encoding differentisoforms.
Oram, S.H., et al. Oncogene 29(43):5796-5808(2010)Younes, S.F., et al. Am. J. Surg. Pathol. 34(9):1266-1276(2010)Hirose, K., et al. Blood 116(6):962-970(2010)Durnick, D.K., et al. Am. J. Clin. Pathol. 134(2):278-281(2010)Cobanoglu, U., et al. Hematology 15(3):132-134(2010)
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