|Other Names||Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9, RHOC, ARH9, ARHC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14105b was selected from the C-term region of RHOC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner|
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This gene encodes a member of the Rho family of smallGTPases, which cycle between inactive GDP-bound and activeGTP-bound states and function as molecular switches in signaltransduction cascades. Rho proteins promote reorganization of theactin cytoskeleton and regulate cell shape, attachment, andmotility. The protein encoded by this gene is prenylated at itsC-terminus, and localizes to the cytoplasm and plasma membrane. Itis thought to be important in cell locomotion. Overexpression ofthis gene is associated with tumor cell proliferation andmetastasis. Multiple alternatively spliced variants, encoding thesame protein, have been identified.
Jiang, L., et al. Int. J. Cancer 127(3):505-512(2010)Wu, M., et al. Cancer 116 (11 SUPPL), 2768-2782 (2010) :Lipkin, S.M., et al. Cancer Prev Res (Phila) 3(5):597-603(2010)Kitzing, T.M., et al. Oncogene 29(16):2441-2448(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)
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