|Other Names||Nuclear factor 1 A-type, NF1-A, Nuclear factor 1/A, CCAAT-box-binding transcription factor, CTF, Nuclear factor I/A, NF-I/A, NFI-A, TGGCA-binding protein, NFIA, KIAA1439|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP14133b was selected from the C-term region of NFIA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.|
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Provided below are standard protocols that you may find useful for product applications.
Nuclear factor I (NFI) proteins constitute a family ofdimeric DNA-binding proteins with similar, and possibly identical,DNA-binding specificity. They function as cellular transcriptionfactors and as replication factors for adenovirus DNA replication.Diversity in this protein family is generated by multiple genes,differential splicing, and heterodimerization.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Starnes, L.M., et al. Blood 114(9):1753-1763(2009)
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