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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Mouse Map2k7 Antibody (Center) Blocking peptide   

Mouse Map2k7 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8CE90
Clone Names 110316222
Peptide ID 110316222
Additional Information
Gene ID 26400
Other Names Dual specificity mitogen-activated protein kinase kinase 7, MAP kinase kinase 7, MAPKK 7, JNK-activating kinase 2, MAPK/ERK kinase 7, MEK 7, c-Jun N-terminal kinase kinase 2, JNK kinase 2, JNKK 2, Map2k7 {ECO:0000312|MGI:MGI:1346871}
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14155c was selected from the Center region of Mouse Map2k7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Map2k7 {ECO:0000312|MGI:MGI:1346871}
Function Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Cellular Location Nucleus. Cytoplasm
Tissue Location Expressed at high levels in brain, lung, liver, skeletal muscle, kidney, and testis and at lower levels in the heart and spleen.
Research Areas
Citations (0)

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Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.


Bogani, D., et al. PLoS Biol. 7 (9), E1000196 (2009) :Derradji, H., et al. Dev. Biol. 322(2):302-313(2008)Nishitai, G., et al. J. Cell. Biochem. 104(5):1771-1780(2008)Wang, X., et al. Mol. Cell. Biol. 27(22):7935-7946(2007)Jaeschke, A., et al. Mol. Cell 27(3):498-508(2007)

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$ 80.00
Cat# BP14155c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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