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Mouse Pxk Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8BX57
Clone Names 110316367
Peptide ID 110316367
Additional Information
Gene ID 218699
Other Names PX domain-containing protein kinase-like protein, Modulator of Na, K-ATPase, MONaKA, Pxk {ECO:0000312|MGI:MGI:1289230}
Target/Specificity The synthetic peptide sequence used to generate the antibody AP14159c was selected from the Center region of Mouse Pxk. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pxk {ECO:0000312|MGI:MGI:1289230}
Function Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also associates with the plasma membrane
Tissue Location Isoform 1 is present in all tissues examined. Isoform 2 is found in all tissues except skeletal muscle and very low levels in spleen. Both isoforms are widely expressed throughout the nervous system however levels of isoform 2 are higher in purified hippocampal and cortical neurons whereas glial cells express more isoform 1 than isoform 2
Research Areas
Citations (0)

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Background

Pxk binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

References

Mao, H., et al. J. Neurosci. 25(35):7934-7943(2005)Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)

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$ 80.00
Cat# BP14159c
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