UBP46 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P62068 |
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Clone Names | 110330014 |
Gene ID | 64854 |
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Other Names | Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46, USP46 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP14161b was selected from the C-term region of UBP46. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | USP46 |
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Function | Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). |
Cellular Location | Cytoplasm. Note=USP46/WDR48/WDR20 complex is predominantly cytoplasmic |
Tissue Location | Broadly expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Modification of cellular proteins by ubiquitin is anessential regulatory mechanism controlled by the coordinated actionof multiple ubiquitin-conjugating and deubiquitinating enzymes.USP46 belongs to a large family of cysteine proteases that functionas deubiquitinating enzymes (Quesada et al., 2004 [PubMed14715245]).
References
Kushima, I., et al. J. Hum. Genet. 55(3):133-136(2010)Cohn, M.A., et al. J. Biol. Chem. 284(8):5343-5351(2009)Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009)Quesada, V., et al. Biochem. Biophys. Res. Commun. 314(1):54-62(2004)Puente, X.S., et al. Nat. Rev. Genet. 4(7):544-558(2003)
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