|Other Names||Chordin, CHRD|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1416a was selected from the N-term region of human CHRD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).|
|Tissue Location||Expressed at the highest level in liver.|
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Provided below are standard protocols that you may find useful for product applications.
CHRD is a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. This protein may also have roles in organogenesis and during adulthood.
Lim,J., Cell 125 (4), 801-814 (2006)Moll,F., FASEB J. 20 (2), 240-250 (2006)
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